Regulatory authorities must ditch double standards and push for more research
Bravery, stupidity, or vested interests? These are some possible characteristics of those who are desperately trying to force the retraction of the study by Séralini et al about the long-term risks of eating genetically modified (GM) crops. As we indicated in our previous article on the subject, the study wasn’t perfect. Few are. But what’s needed is more research – not burial of Séralini et al’s findings. But will the European Food Safety Authority (EFSA) listen?
EFSA published its initial review on 4th October, declaring Séralini's paper to be, “[Of] insufficient scientific quality to be considered as valid for risk assessment”. Its criticisms included several of the points made by the Science Media Centre, ourselves and others, and went further. EFSA alleged, among other things, that the authors had not followed specific Organisation for Economic Cooperation and Development (OECD) guidelines specifying a minimum of 50 rats per group for an experiment such as this. The Authority asked for further information in advance of its final determination, promised for the end of October 2012.
Cloak and dagger science
At this point, it is useful to highlight that Prof Séralini had felt compelled to perform his experiment under conditions of strict secrecy, to avoid it being scuppered by the biotech industry. The study authors even took the unusual, and unpopular, step of asking journalists to sign a non-disclosure agreement prior to receiving the study text.
In this context, what happened next is less surprising: Prof Séralini refused to hand over his data to EFSA, claiming that his study exceeded the level of scientific rigour employed in the studies used by EFSA to approve many GM crops. Publicly release all of the data relating to GM crop approvals, said Séralini to EFSA, and I will do the same – then we can all see who is doing the 'best' science on GM crops.
On 22nd October, EFSA complied with Séralini's request, or so it claimed. But, in a French article translated by GM Watch, Séralini's group accused EFSA of “bad faith”: “There are no biological data (analyses of blood and tissues) on which you can work. This is really a con trick".
NGO to the rescue
In the absence of definitive data from EFSA, it was left to the non-governmental organisation Testbiotech to take a close look at the studies EFSA deemed acceptable for approval of GM crops – and to compare them with Séralini's paper. Its report, entitled The double standards of EFSA, is essential reading for anyone wishing to understand the finer details of this affair.
The report points out that EFSA has been inconsistent when handling scientific research. When it's a GM crop produced by Monsanto and other biotech companies, EFSA has happily accepted scientific standards well below those the Authority now chooses to apply to Séralini's paper. According to Testbiotech, “EFSA does not apply OECD standards to sub-chronic, 90 day feeding studies when these are prepared by industry and do not show health effects from consuming genetically engineered foods. In contrast, the OECD standards have been used by EFSA to attack the research of Séralini et al”.
It's the same picture with chronic and generational feeding studies – even though, “Very few have so far been conducted using plants that are actually authorised in the EU and assessed by EFSA”. Testbiotech examined several such studies and concluded: “None of [the papers] describing chronic feeding studies with genetically engineered plants have met the standards being used by EFSA to criticize the research of Séralini et al., 2012”. Table 1 illustrates this point by comparing the Séralini paper with several trials included in a review of chronic and generational studies, performed by Snell et al, which EFSA accepted. The Snell review is often used to defend the long-term safety of GM crops by the biotech industry and regulators. EFSA, of course, doesn't see any of this as double standards at all.
Table 1. Comparison of the Séralini et al study on GM maize NK603 and Roundup fertiliser with other long-term feeding studies on GM plants, which have been accepted by EFSA. From Testbiotech backgrounder, The double standards of EFSA.
No-one is saying that the Séralini et al paper was perfect, but it's becoming clearer every day that it should be used as a launchpad for further research. Unfortunately, to us, this looks like the story of Dr Arpad Pusztai all over again. Let's hope that there's a better outcome this time, for the sake of science and public health. We will, of course, keep you informed.
Call to action
Write to Elisabeth Waigmann, head of the EFSA’s GMO panel (e-mail: [email protected]) and demand that EFSA apply the same standards when assessing the evidence about GM crops, whether it comes from the biotech industry or from independent scientists. You may also wish to ask why EFSA has condemned the Séralini et al paper as being of such poor quality that it cannot contribute to risk assessment, when it has accepted other papers written to a lower level of scientific rigour than Séralini's, and if EFSA intends to release the remaining data requested by Prof Séralini. Finally, you could ask EFSA whether it is prepared to ignore the Séralini et al paper altogether, or if it will push for the study to be replicated by an independent group, either under identical conditions or under conditions that EFSA deems acceptable. We suggest that you copy your email to EFSA’s executive director, Catherine Geslain-Lanéelle (e-mail: [email protected]) and Dr. Djien Liem, Head of EFSA's Scientific Committee (e-mail: [email protected])
You could also address these questions to your MEP for she or he to raise with EFSA. The more directions used, the more likely it is that EFSA will be forced to respond.